A paper in Environmental Health Perspectives links organophosphate (OP) insecticide exposures during fetal development to predisposition to metabolic syndrome. A key new mechanism leading to adverse developmental outcomes is described – alteration of the trajectory of cell signaling in liver cells “…in a manner consistent with the observed emergence of prediabetes-like metabolic dysfunction.”
Souce: Adigun, A.A., et al., “Neonatal Organophosphate Pesticide Exposure Alters the Developmental Trajectory of Cell-Signaling Cascades Controlling Metabolism: Differential Effects of Diazinon and Parathion,” Environmental Health Perspectives, Vol. 118, No. 2, pages 210-215, February 2010.
